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Many organs and tissues express vitamin D receptors, suggesting that vitamin D affects physiological functions beyond its role in maintaining bone health [1,2,3] and is crucial for the regulation of numerous important genes [4]

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Annu Rev Immunol (2020) 38:289313

Another interesting compound, quercetin, has been shown to inhibit the activity of CD38 by binding to its active site, which results in increased intracellular NAD + 143

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The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below