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The best answer is that phase 2 results were dose-dependent and substantial on average, while individual response varied

Regular meal times help keep the GLP-1 "clock" synchronized

Weight management concerns should be discussed with a qualified healthcare provider familiar with the individual's personal medical history

But for researchers who find the GI effects of full weekly doses difficult to manage, the trade-off is often worth it

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[15] However, subsequent analysis revealed important context: the increased risk was predominantly observed in patients with pre-existing diabetic retinopathy and those who experienced rapid improvements in glycaemic control