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While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

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And these drugs carry their own side effect profile nausea, gastrointestinal issues, and in rare cases more serious complications that need to be weighed carefully

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Additionally, nitric oxide works as an antioxidant that reduces the possibility of immune cells adhering to artery walls