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P MJ, Jurica J, Pov M, et al

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If your genetic profile shows high-sensitivity markers, starting with PlexusDx's Microdose GLP-1 Protocol ($129/mo flat) instead of standard-dose semaglutide ($189/mo) may minimize constipation while maintaining weight loss efficacy

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Novo Nordisk announced the introductory tier when the FDA approved oral semaglutide for weight loss in late December 2025 the goal was to drive trial and adoption when the pill launched broadly in January

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