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Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically available formulations like thiamine tetrahydrofurfuryl disulfide (TTFD)

Lancet 402(10405):871-881, 2023

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Many researchers report significant changes in food preferences, naturally gravitating toward smaller portions and less calorie-dense foods

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The ideal dosage to be injected would be between 10 to 20 mg/kg