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Above a cytotoxic threshold, ROS-induced oxidative stress (OS) would be detrimental to cancer cells and lead to apoptosis or senescence

Functional receptors for glucagon-like peptide-1-(7-36)amide on a somatostatin secreting cell line

Acknowledgements All the figures in the manuscript were drawn by Figdraw

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Of significance and supporting a potential anti-cancer action of metformin is that LKB1 is a tumor suppressor and that mutations in LKB1 are observed in numerous cancers that result in the reduction of the inhibitory effect of the LKB1/AMPK pathway on the pro-proliferative signaling via mTOR (125, 126)

10.3389/fnins.2016.00080 18 FryeR