1) Moreover, several large, prospective, randomized studies have been developed to investigate the association between GLP-1 RAs intake in DM 2 patients and a known cardiovascular disease (CVD) or high cardiovascular (CV) risk
In a single piece, he concisely captures: the state of the field the most important clinical trials where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly semaglutide + once-weekly insulin Even more exciting
GLP-1RAs improve risk factors for CV disease, including weight loss, blood glucose control, blood pressure reduction, and lipid improvement
The four agreement metrics were met (Table 2)
Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study
To help you understand why the tips above matter, its important to look at how semaglutide works