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This is consistent with tolerance of K1A substitution in human Amy (hAmy) for cAMP potency at AMYRs 18

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Each injection produces a spike that rises and falls quickly, more closely mimicking the body's natural secretion pattern

Together, our findings link -KG to energy sensing through AMPK translation and propose that targeting -KGYBX1-dependent AMPK translation can sensitize human cancer cells to energy stress for treatment