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Clinical Efficacy (Phase 2): In trials, high doses (9 mg) led to a mean body weight reduction of roughly 20.1% (-21.3 kg) over 48 weeks

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The two dont have to be mutually exclusive, but any peptide therapy in this context needs to account for the full hormonal picture, thyroid, cortisol, estrogen, not just body weight

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Appl Environ Microb 78(15):54355439

The activation of these receptors appears to trigger a release of growth hormone from pituitary cells