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Mechanisms of desensitization share common features (phosphorylation, accessory proteins involvement such as arrestin, importance of endocytosis and receptor trafficking) and will dependent not only on agonist (biased agonism) but also on time exposure, cell system and receptor

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Our findings demonstrated that PPARa transcriptionally upregulates FSP1, thereby suppressing neuronal lipid peroxidation during the acute phase of TSCI

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