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Tofacitinib: a review in rheumatoid arthritis

The drugs that lose the most weight also produce the most gastrointestinal illness nausea, vomiting, diarrhoea and the highest rates of patients stopping treatment because they cannot tolerate it

For that group, treating the deficiency is important, because an untreated deficiency does not stay still

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The long-term benefits and optimal dosing require further investigation

However, since some effects, such as those on inflammation, were only observed in SD-fed subjects, it is possible that the dose was not high enough to counteract the effects of the WD, and a higher dose may have led to reductions in WD-fed rats