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Furthermore, in some tumours, the need for methyl groups for epigenetic regulation prevents activation of the trans-sulphuration pathway for cysteine synthesis, instead prioritising one-carbon metabolism
However, it is not recommended for use in newborns or premature infants, as neonates lack the metabolic capacity to process benzyl alcohol safely a contraindication explicitly noted in FDA guidance on benzyl alcohol toxicity in neonates
Similar results in gastric cancer were described by OLeary et al., whereby high-dose VitC (4 g/kg IP daily) was injected in combination with carboplatin (15 mg/kg weekly), paclitaxel (10 mg/kg) and 2Gy IR/8fx [89]
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Blood samples were collected at 0, 0.25, 0.5, 1, 2, 4, 6, and 15 hours after alcohol consumption to measure both alcohol and acetaldehyde levels using validated assay kits, capturing key pharmacokinetic parameters such as maximum serum concentration (Cmax) and area under the curve (AUC)
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