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In DKD, upregulation of local angiotensin II in the renal tubule, activation of vascular endothelial growth factor (VEGF), and reduction of nitric oxide (NO) ( Activation of RAAS also leads to the release of aldosterone, a mineralocorticoid hormone, from the adrenal glands

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This has been seen in both immunocompetent and immunocompromised HBV transgenic mouse models

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