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2 Ferroptosis in OA: molecular mechanisms and pathological significance 2.1 Ferroptosis in OA pathogenesis: emerging connections Characterized by iron dysregulation and lipid peroxide overload, ferroptosisoriginally triggered by the small molecule erastinwas formally defined in 2012 by Dixons seminal work (Yang J
Dasatinib has shown antifibrotic effects in keloid fibroblasts and xenotransplant keloid tissue in mice through the selective clearance of senescent cells and modulation of SASP, implying that dasatinib can be possibly used for senolytic treatment of keloids 15
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Key downstream effectors of p53 include Mouse Double Minute 2 (MDM2) and cyclin-dependent kinase inhibitor 1 (p21), which mediate critical regulatory pathways in breast cancer
