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The comparison is clear: MK-677: small-molecule GHSR agonist IGF-1 LR3: modified insulin-like growth factor analogue MK-677: GH axis and IGF-1 marker response IGF-1 LR3: direct IGF-1R pathway research MK-677: non-peptide secretagogue IGF-1 LR3: peptide growth factor analogue Both may appear in growth factor and myogenic research conversations, but they should not be described as the same type of compound

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