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GHK-Cu modulates the expression of a large number of human genes studies using gene expression microarrays have identified over 4,000 genes whose expression is influenced by GHK-Cu, with effects spanning multiple functional categories including tissue remodeling, antioxidant defense, and growth factor signaling

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Factors such as aging, stress, illness, and environmental exposure can contribute to lower glutathione levels over time

This includes SSRIs (such as Zoloft, Prozac, Celexa, and Paxil), SNRIs (such as Effexor and Savella), MAOIs, tricyclic antidepressants, and some mood stabilizers like lithium