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The FDA has recognized allulose as Generally Recognized as Safe (GRAS) and under enforcement discretion permits its exclusion from total and added sugars labeling, though it still counts toward Total Carbohydrate on nutrition labels

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A Phase 1 clinical trial conducted in healthy subjects (168) revealed that Sh28GST induced IgG1 and high IgG3 titers, an effect that was associated previously with reduced egg production and decreased urinary tract pathology among Sh-infected individuals

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