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5 This process induces oxidative stress and mitochondrial dysfunction, resulting in hepatocyte necrosis and the release of cellular contents, including DAMPs

Besides, goiter may be experimentally induced in animals exposed to goitrogenic substances, like perchlorate or thiocyanates, which block iodine uptake in the thyroid gland, causing a similar compensatory rise in secretion of TSH and hyperplasia of thyroid cells (Nourani and Sadr 2023)

Cagrilintide and tirzepatide are discussed together because both are once-weekly injectables that reduce appetite and bodyweight, and both slow gastric emptying as part of that effect

One notable exception is oral semaglutide (Rybelsus) for diabetes treatment, which uses special absorption enhancement technology

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The injection must be given by a healthcare professional