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The Journal of Biological Chemistry, 289(28), 1950819518

2026 Aug 1:251:229-242

Osteoarthritis Cartilage 29 , S410S411 (2021)

J., van Engeland, H

During endothelial dysfunction, structural and functional abnormalities arise in the endothelial cells, impairing their ability to regulate vasodilation, thrombosis, and vascular wall repair

Prior art literature such as United States Patents US4797284 and US4880633 had employed propylene glycol as a penetration enhancer which is gelled with 2 percent hydroxypropyl guar (HP-60 Jaguar from Celanese) which served as a dissolved drug reservoir