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Several GPs that showed significant fold changes in subjects with metabolic syndrome had also shown similar changes (e.g., increase or decrease) at the end of 4th week during 30-day intermittent fasting (KIT, CROCC, DNTT, POLK, SRGN, CLSTN1) and 1 week after 30-day intermittent fasting (PRKCSH, CALU, SPECC1L, IGFBP4, MYH7, CDH6, H2B histone, PKP1, LRRC3, FGB, ENPP2) in our previous study conducted in healthy subjects although they had not reached statistical significance 15

The votes arent binding and the FDA has periodically bucked the recommendations of its outside experts

Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT et al (2013) Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinsons disease

doi:10.1016/j.cmet.2022.07.013