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The alteration of the BBB is often marked by a degradation or shrinkage of ECs, alteration of the tight junction proteins connecting cells and modified transport mechanisms which all together impact greatly the BBB permeability
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Studies report modulation of NO synthase activity and interaction with NO-mediated tissue protection pathways, which may underlie its broad cytoprotective profile
Londhe AM, Gadhe CG, Lim SM, Pae AN (2019) Investigation of molecular details of keap1-nrf2 inhibitors using molecular dynamics and umbrella sampling techniques
