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ROS is generated when MOG is added to unstimulated -cells ( Saccharin Increases ROS in -Cells and Fat Cells Artificial sweeteners affect insulin secretion in rat islets: All sweeteners tested generated ROS and increased insulin secretion at low non-stimulatory glucose

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Lindbom L, Pihlgren P, Jonsson EN

In non-diabetic-subjects bile acid sequestrants have reduced cardiovascular events (425,426)