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For the estimated 100 million Americans with fatty liver disease, this difference could be clinically transformative
GLP-1 expression was downregulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expression of lipolysis and autophagy-related genes and proteins were also inhibited, such as adipose triacylglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and hepatic lipase deficiency gene (LIPC)
This can only be partially attributed to weight loss [21] reported a weight-independent effect of GIP receptor stimulation on insulin sensitivity
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Tirzepatide goes further, activating both GLP-1 and GIP receptors