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Bioinformatics 2022, 38, 3121

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In fact, a 2023 paper published in the Journal of Cerebral Blood Flow & Metabolism reported that methylene blue (in similar doses studied by researchers at The University of Texas at Austin who claimed the compound had memory-enhancing properties) led to a 8% decrease in human brain blood flow

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Combining them, especially when you're new to either ingredient, increases the likelihood of redness, peeling, and discomfort