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Common adverse effects include nausea, vomiting, diarrhoea, and constipation, which typically diminish over time

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Thermal sensitivity measurement (Hargreaves test) On the day of the behavioral experiment, the mice were initially given a one-hour period to acclimate to the plexiglass chambers, which measured 6.5 6.5 6 cm, on the Hargreaves Apparatus (IITC Life Science Inc., CA, USA)