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This can occur due to the enlargement of the left ventricle (dilated cardiomyopathy), abnormal thickening of the heart muscle (hypertrophic cardiomyopathy), or stiffening of the heart muscle that prevents it from adequately expanding and filling with blood (restrictive cardiomyopathy)

Liu J, Zhu S, Zeng L, Li J, Klionsky DJ, Kroemer G, et al

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The apoplastic generation of ROS occurs mainly by enzymes like membrane NADPH-dependent oxidase, cell wall peroxidase or polyamine oxidases (Bolwell et al., 1994)

Perron U, Grassi E, Chatzipli A, Viviani M, Karakoc E, Trastulla L, et al