J Hepatol 2024;81:492-542.ArticlePubMed 100
The PCOS-Insulin Connection Most Doctors Miss Your doctor probably told you that PCOS is about "cysts on your ovaries" or "hormone imbalance." What they likely didn't explain is that for up to 80% of women with PCOS, insulin resistance is driving the entire show
What approach do you recommend dermatologists take with patients who are either currently on or are considering using GLP-1 agonists
A., GLP-1 Receptor Agonists and Colorectal Cancer Risk in Drug-Naive Patients With Type 2 Diabetes, With and Without Overweight/Obesity, JAMA Oncol, Dec
Obstructive Sleep Apnea SURMOUNT-OSA trials investigated GLP2 in adults with moderate-to-severe obstructive sleep apnea and obesity: Significant improvements in apnea-hypopnea index (AHI) from baseline Benefits observed in participants both using and not using positive airway pressure therapy Improvements correlated with weight reduction FDA approval granted in December 2024 for moderate-to-severe OSA treatment Diabetes Prevention Extended follow-up from SURMOUNT-1 assessed diabetes prevention in participants with prediabetes: 94% reduction in progression to type 2 diabetes compared to placebo over 3 years Nearly all participants with prediabetes at baseline converted to normoglycemia Effects diminished during off-treatment follow-up period, indicating ongoing treatment benefit [CALLOUT BOX Highlighted] Important Context: While GLP2 has demonstrated substantial efficacy in multiple large-scale clinical trials, the majority of data comes from industry-sponsored studies with relatively short follow-up periods (40-72 weeks for most trials)
Certain nutrients are direct triggers of this hormone
