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Free radicals are capable of initiating these changes due to the presence of unpaired electrons in their structure (84, 87)

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In women with PCOS, hyperandrogenism, insulin resistance, and adipose-derived inflammatory cues have been associated with altered neutrophil activation profiles, including increased oxidative stress, degranulation, and markers suggestive of neutrophil extracellular trap (NET) formation

Gombik K, Detka J, Bobula B, Bk J, Kusek M, Tokarski K, Budziszewska B (2021) Contribution of hypothyroidism to cognitive impairment and hippocampal synaptic plasticity regulation in an animal model of depression

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