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These symptoms are not unique to retatrutide and are commonly seen across GLP-1-based therapies

Makhija et al

Why Wegovy May Affect Mood: The Science Explained Wegovy may affect mood because GLP-1 receptors influence appetite, reward signals, energy balance, and emotional pathways in the brain

J Am Coll Cardiol 2023;81:1902-14.ArticlePubMed 113