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Moreover, the LN microenvironment accelerates epigenetic (60) and metabolic reprogramming of cancer cells (61, 62) that promote resistance to ferroptosis, enhancing survival and metastasis through the blood (62)

Given that both peptide 15 and peptide 20 are modified forms of GCG (differed by 7 residues), ligand recognition patterns are highly conserved across the three peptides except for a few positions

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Such effect was evidenced by increased expression of p65 NF-B, as well as enhanced IL-1 and TNF- levels in both examined brain regions

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