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intramuscular route: count injections given Visit 3 (week 26) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaire: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication

Results of the root cause verification The survey results were analysed and presented in the form of a Pareto chart (Fig

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Poor growth rates and ill thrift may be seen in affected animals

Some P.A

Drug approval requires demonstrated efficacy plus safety