Creatine is the most researched supplement by a long shot
Conservative dosing also reduces risk of excessive energy deficit and the metabolic stress markers (low T3, menstrual irregularity) that emerge when both compounds are pushed to upper dose ranges simultaneously.
If you have TRICARE For Life Weight-loss medications like Wegovy and Zepbound are no longer covered when prescribed for obesity alone
The exact oral bioavailability has not been formally determined, but the systemic effects observed after oral administration suggest significant absorption
Additional testing if symptomatic: Iron studies if fatigued, magnesium if experiencing cramps, and amylase/lipase if experiencing persistent abdominal pain (to rule out pancreatitis, a rare but serious side effect)
For these patients, being able to stop thinking about food is a relief, and can lead to an overall healthier lifestyle