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Leptin receptor-deficient db/db mice were purchased from the Jacksons Laboratory (Strain 000697)
GLP-1 medications slow down how quickly food leaves your stomach (gastric emptying)
Attaching a 16-carbon side chain (palmitic acid) to the peptide allowed the molecule to bind to the abundant blood protein albumin and keep it in circulation
GLP-1s, first approved for type 2 diabetes in 2005, lower blood glucose, help avoid fatty liver disease, and help with obesity-related problems such as knee pain, sleep apnea, and gastroesophageal reflux
Clinical predictors of suicidal ideation, suicide attempts and suicide death in depressive disorder: a systematic review and meta-analysis