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We demonstrate that the therapeutic potential of GLP-1RAs in RA is mediated by their dual targeting of two key pathological pathways: suppressing a previously unidentified cGAS-STING-ferroptosis axis in chondrocytes and reprogramming synovial macrophages toward an M2 reparative phenotype, which collectively helps maintain joint homeostasis
However, this is a signal that is not present with either semaglutide or tirzepatide
Heme iron is better absorbed than non-heme iron, and some dietary components can inhibit (phytates in whole grains, legumes, and nuts
This is a critical counseling point: the worst outcomes are associated with stopping Ozempic with no transition plan
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