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The combination of peak drug levels and a full stomach is a recipe for trouble

it does not force the body to oxidize it

Turns out I was making two mistakes without realizing it

Phase II Jastreboff 2023 NEJM: -24.2% at 12mg/48w for retatrutide vs SURMOUNT-1 Jastreboff 2022: -20.9% at 15mg/72w for tirzepatide

References: Centers for Disease Control and Prevention, National Center for Health Statistics

Key Takeaways GLP-1 receptor agonists (GLP-1RAs) are a critical advancement in managing type 2 diabetes and obesity, offering significant benefits in blood sugar control and weight loss, but differ in their mechanisms of action, dosing schedules, and side effects