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Chi HJ, Chen ML, Yang XC, et al

While some of these effects can be beneficial in specific contexts, they create complexity, side effects, and potential contraindications that limit the applicability of growth hormone therapy for individuals seeking primarily fat loss

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Although we have acquired knowledge about some toxic lipid states, including lipid membranes and lipid droplets of aberrant compositions, and peroxidated lipids (Figure 2), as well as about some toxic protein states, including misfolded oligomers (Figures 35), it is likely that additional toxic states will emerge, providing novel insights and mechanistic details of the connections between proteotoxicity and lipotoxicity

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