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The first seven trials involved patients with T2DM and baseline glycated hemoglobin levels ranging from 7.3 to 8.7, whereas the most recent SELECT trial focused on nondiabetic patients with overweight or obesity and preexisting cardiovascular disease

The latter causes GSH to become reactive and form a disulphide bridge with another reactive GSH molecule to form a GSSH disulphide (Reference Kapun, Salobir and Levart41)

That is why treatment for a confirmed deficiency often starts with a higher frequency, sometimes weekly, for a defined period

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