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Most studies focused on liraglutide, whereas the newer GLP-1RAs have better appetite-suppressant and weight-reduction actions

The STEP trials are testing semaglutide at the higher dose of 2.4 mg/week (as compared to 1.0 mg/week for the original diabetes indication), specifically for promoting weight loss, regardless of the presence of type 2 diabetes

Weight loss typically follows soon after, with steady progress over time

Countries, such as China, Japan, and India, are witnessing rapid adoption of GLP-1 therapies backed by local manufacturing and import facilitation

A more likely contributor

Clinical adverse events associated with sodium-glucose cotransporter 2 inhibitors: a meta-analysis involving 10 randomized clinical trials and 71 553 individuals