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Tazemetostat is a type of histone methyltransferase inhibitor therapy used to treat soft tissue sarcoma

Three RCTs [18, 32, 33] involving 192 patients provided moderate certainty evidence (Table 2) that L-carnitine supplementation probably has little or no difference in adverse events (RR: 0.72, 95%CI: 0.47 to 1.08)

25 A nerve biopsy of the first known patient with the ACOX1 N237S mutation revealed a loss of Schwann cells

Therefore, the data were pooled for a given treatment (SL, PO) to analyze the results ( n =20 for each treatment)