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Discussion Keys findings In our study, using a fully resuscitated large animal model, we demonstrated that inhibition of DPP3 with PCZ was associated with 1/ Decreased catecholamine and fluid requirements with comparable organ perfusion, as assessed by an isotopic method, 2/ Lower vascular and myocardial inflammation, 3/ Lower myocardial injury and 4/ Better pulmonary function, as reflected by higher PaO 2 /FiO 2 ratio