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2 Research has shown that rolling a dermaroller (with 192 needles, 200 m in length, and 70 m in diameter) over an area 15 times results in approximately 250 holes per cm 2 , thus the dermaroller used in this study possibly produced 703 holes approximately per cm 2

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There was no difference in the subgroups (Supplement S10), indicating the robustness of the results

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