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In DIO rats, RM-718 demonstrated comparable activity to setmelanotide on weight and food intake reduction in a 14-day study (130)

Reports suggest possible risks related to hormonal changes and skin pigmentation disorders

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While current TCM research remains largely phenomenological, studies on its direct anti-ferroptotic effects and microbiota-mediated mechanisms require substantial expansion

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Eloralintide phase 2 trial results reveal weight loss of up to 20% over 48 weeks, along with improvements in LDL, triglycerides, and inflammation markers