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Lipofuscin generates a large amount of ROS under blue light irradiation, which triggers endoplasmic reticulum stress (ER stress) in RPE cells, manifested by upregulation of GRP 78 and CHOP protein expression, and then induces cell apoptosis through activation of Caspase-3 and decreased expression of Bcl-2 (Zhao, 2015)

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If you cannot do strong contrast, do local contrast on your head by putting it under cold water

It doesnt mean the medication doesnt work, it just means that you need to find the most effective dose for you

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