Article updated 12/17/2025 to reflect recent FDA communications, regulatory clarifications and clinical context related to GLP-1 medications
It described the layoffs as a way to respond to and stay ahead of industry-wide developments, including the growth of GLP-1 drugs and rising expectations for drug quality
So, yes reduction of body fat mass while maintaining or building lean body mass is possible, which involves resistance training, an individualized healthy rate of fat loss, macronutrient / calorie modulation, high protein, supplements / nutraceuticals, plenty of low carb vegetables, etc
doi: 10.1038/s41584-025-01302-0
Different Hormonal Strategies Target Different Physiological Domains The third principle is that the specific combination of hormones prescribed shapes which aspects of the menopausal disruption are most directly addressed
GLP-1 drugs show promise for weight management Across the reviewed studies, tirzepatide, semaglutide, and liraglutide consistently led to significant weight loss over one to two years compared with placebo, and the benefits appeared to continue during ongoing treatment