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Once within the mitochondria, PGAM5 dephosphorylates AIFM1 at Ser116, ultimately resulting in the induction of oxeiptosis in HeLa cervical cancer cells [74]

The authors also reported that the use of chemotherapy has demonstrated low response rates and yielded no clear mortality benefit in the treatment of MMNST

Imbalances in the interactions between glutamate and glutathione may lead to impaired redox signaling and neuronal abnormalities