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Glutathione is called an antioxidant because of its role in protecting cells from the damaging effects of these unstable molecules

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49 For example, glutamine enhances superoxide production in neutrophils via the generation of ATP and the regulation of NADPH oxidase expression

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Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close