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Oncogene 38 , 47294738 (2019)

Compared with vehicle-treated obese mice, the treated animals showed reductions in body-weight measures, white-adipose mass and adipocyte size

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Future studies will reveal the applicability of our model, for example, to activate enzymatically inactive glutaredoxins, to alter the sensitivity and responsiveness of glutaredoxin-coupled fluorescent redox sensors, to further address the catalytic mechanism with GSSCys, HEDS and physiological substrates, or to design specific transition-state inhibitors

Lactated Ringers solution was provided intravenously at 10 mL kg per hour throughout anesthesia