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The pilot allows the agency to work with manufacturers to determine when it will exercise enforcement discretion on certain product requirements to promote wider access to digital health products

227 Bile acids, synthesized in the liver through the cholesterol metabolism pathway, act as ligands for the transmembrane G protein-coupled receptor 5 (TGR5) and increase intestinal GLP-1 secretion

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Sirtuin 1 regulates mitochondrial biogenesis and provides an endogenous neuroprotective mechanism against seizure-induced neuronal cell death in the hippocampus following status epilepticus

Secondary end points included the percentage change in body weight from baseline to 48 weeks and a weight reduction of 5% or more, 10% or more, or 15% or more

While this review focused primarily on adult populations, there is limited research available on the use of GLP-1 therapies in pediatric patients