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PMID: 25489333

Effect of synthetic cell-binding peptide on the healing of cortical segmental bone defects

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Substituting arginine for glutamate at this position markedly reduces the analogs affinity for the IGFBPs while leaving its ability to engage the type 1 IGF receptor (IGF-1R) largely intact

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In cases where OTC medications are not effective or acne has worsened, professional medical treatment is necessary