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OS (oxidative stress) is a main cause of neurodegeneration and its involvement in the pathogenesis of major depressive disorder is unequivocally established (PubMed.ncbi.nlm.gov). Youre probably thinking, Okay, I have seen a glutathione supplement at my local grocery store, Ill just pick that up. According to PubMed, Glutathione has a very low bioavailability, meaning that it is not easily absorbed through oral supplementation

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15 These results support the hypothesis that NAC is capable of crossing the bloodbrain barrier and providing cysteine substrate to CNS cells, thus enhancing GSH synthesis

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Direct Replenishment 900mg reduced glutathione for immediate antioxidant activity